Granular Cell Tumor
55 year-old man undergoing colonoscopy for evaluation of occult bleeding. In addition to several benign tubular adenomas, colonoscopy revealed this smooth polypoid lesion. On microscopic exam, the lesion contained cytologically bland cells with abundant granular cytoplasm, small regular nuclei involving musoca and apparently associated with, or arising from, the muscularis mucosa, consistent with granular cell tumor. Granular cell tumors may occur elsewhere in the GI tract, including the esophagus.
50 year-old man undergoing colonoscopy for average risk colon screening. Smooth submucosal polypoid lesion in the cecum measuring 5-7 mm in diameter proved to be a benign granular cell tumor on biopsy. The appendiceal orifice is also visible to the right of the lesion.
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