72 year-old woman who presented with abdominal pain, bloody diarrhea and weight loss. She had been taking significant amounts of nonsteroidal antiinflammatory agents (NSAIDs) for arthritis. Colonoscopy revealed segmental mucosal inflammation with ulceration. Although grossly similar in appearance to ischemic colitis, the typical histological features of ischemic colitis (mucosal necrosis, fibrosis of the lamina propria and crypt atrophy, and overlying fibrinopurulent membrane) were not present on biopsy.
83 year-old woman who presented with abdominal pain, who had been taking nonsteroidal antiinflammatory agents (NSAIDs) on a daily basis. Colonoscopy revealed a solitary ulcer in the cecum on the wall opposite the ileocecal valve. As in the case above, the typical histologic features of ischemia were not present.
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