57 year-old man with longstanding symptoms of gastroesophageal reflux disease. Squamocolumnar junction (left) was located 15 cm above the esophagogastric junction. View on the right shows the long segment of distal esophagus covered with columnar epithelium.
Left: 47 year-old woman with chronic pyrosis (heartburn). Endoscopy demonstrated an irregular squamocolumnar junction, with bands of metaplastic epithelium extending proximally.
Center: 73 year-old woman with pyrosis and dysphagia (difficulty swallowing). Squamocolumnar junction shown here was located 10 cm above the junction of the stomach and esophagus.
Right: 85 year-old man with chronic gastroesophageal reflux disease, in whom the squamocolumnar junction has migrated upward from the esophagogastric junction in an asymmetric fashion.
Left: Retroflexed view, looking upward at the junction of the stomach and esophagus in a 72 year-old man with Barrett's. The large arrow indicates the squamocolumnar junction, located several centimeters upward in the esophagus. The smaller arrows indicate islands of squamous mucosa left behind in the segment of columnar epithelium.
Center: Segment of Barrett's with residual islands of squamous epithelium.
Right: 71 year-old woman with chronic reflux symptoms. Endoscopy revealed asymmetric proximal migration of the squamocolumnar junction, with small islands of squamous mucosa within the segment of columnar epithelium.
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