Crohn's: Mucosal Features
Left: Normal ileum.
Right: Mucosal inflammation causes redness, friability (ease of bleeding) and edema (swelling), giving rise to a granular appearance. As inflammation extends deeper into the bowel wall, edema results in a cobblestone appearance.
As inflammation progresses, ulcers appear, and may be punctate (left), linear, or more extensive (right). Repeated ulceration causes destruction of mucosa, giving the swollen surviving mucosa a raised, polypoid appearance (pseudopolyps), seen in distance on left and foreground on right.
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