Esophagus Stomach Duodenum Capsule Endoscopy Inflammatory Bowel Disease Colon & Ileum Miscellaneous

Intestinal Metaplasia

Left & Center: 86 year-old woman with protracted nausea, and abdominal discomfort. Endoscopy revealed antral gastritis with pale foci which proved to be intestinal metaplasia on biopsy.

Right: Variegated mucosal appearance in a 73 year-old woman. Biopsy revealed moderate chronic superficial gastritis with extensive intestinal metaplasia; Helicobacter pylori were absent.

Left: 81 year-old man with acid-peptic symptoms. At endoscopy, pale mucosa was noted in the immediate prepyloric antrum. Biopsies revealed intestinal metaplasia.

Center: 64 year-old woman with chronic nausea. The gastric mucosa had a variegated appearance, shown here. Biopsies revealed chronic gastritis with intestinal metaplasia.

Right: Similar variegated mucosal appearance in a 95 year-old woman. Biopsies revealed chronic gastritis with intestinal metaplasia.

Left: Patchy intestinal metaplasia, paler than the surrounding mucosa, in the prepyloric antrum of a 52 year old woman with dyspeptic symptoms. Test for Helicobacter pylori was positive.

Right: 86 year old woman with nausea and weight loss. Endoscopy demonstrated cobblesstone-appearing gastric mucosa. Histology revealed gastric mucosa with nearly all of the functional glandular and pit component replaced by intestinal metaplasia, with patchy chronic inflammation throughout, as well as paneth cell metaplasia; there was no dysplasia or malignancy, and no Helicobacter pylori.

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